Advances in Femtosecond Laser Micro-Nano Processing and Biological Application Research

Recently, Wuhan Sintec Optronics Co.Ltd, has made new progress in femtosecond laser micro-nano processing and biological applications. Femtosecond laser micro-nano processing and two-photon 4D printing is a new research direction opened up by the Micro-Nano Robotics Group, aiming to carry out research on bio-interface regulation and flexible brain-machine interfaces by using femtosecond laser ultra-fast processing to provide new enabling technologies for life science and brain science research. 

Femtosecond laser processing takes advantage of its multiphoton nonlinear absorption property, which has the advantages of high resolution, wide material applicability and low thermal damage. The research team has constructed a dual-wavelength femtosecond laser processing system, which can realise large-scale, three-dimensional high-precision micro-nano processing. In response to the research needs of cell behaviour and cell cluster capture, the research innovatively proposed a single pulse femtosecond laser two-photon polymerisation method, combined with the principle of capillary force self-assembly, to prepare three-dimensional micro-patterned microstructural arrays, and realised the selective growth regulation of MCF-7 cells. The related research results were published in ACS Applied Materials & Interfaces. 

In recent years, the group has carried out a series of research in the field of micro-nano optics and biosensing, and the related results have been published in Advance Sciences (2022), Biofabrication (2022), Lab on Chip (2021/2022), Optical Express (2021), etc., which have received wide attention.